Which molecule is responsible for transporting triglycerides from the liver to tissues?

• A. High-Density Lipoprotein (HDL)
• B. Very Low Density Lipoprotein (VLDL)
• C. Chylomicrons
• D. Low-Density Lipoprotein (LDL)

Answer: (B)

Transport of triglycerides from the liver to tissues is carried by very low density lipoprotein. The liver packages endogenous triglycerides into VLDL and releases them into the bloodstream; lipoprotein lipase on capillary walls then hydrolyzes the triglycerides, supplying fatty acids to muscle and adipose tissue. As triglycerides are unloaded, VLDL becomes smaller and denser, eventually forming LDL, whose primary job is delivering cholesterol to tissues. Chylomicrons carry dietary triglycerides from the intestine, and HDL is involved in reverse cholesterol transport, not delivering TGs from the liver.