Apolipoprotein B is the liver protein that wraps around TAG and cholesterol droplets to form which particle?

• A. High-Density Lipoprotein (HDL)
• B. Very Low Density Lipoprotein (VLDL)
• C. Low-Density Lipoprotein (LDL)
• D. Chylomicron

Answer: (B)

ApoB provides the scaffolding that coats a lipid core rich in triglycerides and cholesterol esters in the liver, forming a particle that the liver exports as very low-density lipoprotein. This VLDL carries triglycerides from the liver to peripheral tissues. As lipoprotein lipase acts, TG are removed and the particle is remodeled into smaller lipoproteins, ultimately yielding LDL. HDL is built with different apolipoproteins (like ApoA) and doesn’t form around hepatic lipid droplets, while chylomicrons are assembled in the intestine with ApoB-48. So the particle formed by ApoB wrapping hepatic lipid droplets is VLDL.